Differences in Subjective Well-Being between Formal and Informal Workers in Urban China.

This paper examines the relationship between different types of employment and subjective well-being with a focus on informal employment. The China Labor-force Dynamics Survey (CLDS) for three selected years (2012, 2014 and 2016) shows an upward trend in the subjective well-being of urban workers in the 2010s. However, although the gap in subjective well-being between formal and informal workers narrowed, informal workers' subjective well-being was still lower than their formal counterparts. Factors affecting the subjective well-being of formal and informal workers and their different effects were revealed to explain this difference. The subjective well-being of informal workers is significantly related to their informal status of employment, economic conditions (such as income and working hours), human capital, social capital (such as perceived social justice and perceived community connectedness) and urban environment. The paper enhances the understanding of people's subjective well-being by differentiating informal/formal segments of working populations.

Discovery of core-structurally novel PTP1B inhibitors with specific selectivity containing oxindole-fused spirotetrahydrofurochroman by one-pot reaction.

Protein tyrosine phosphatase 1B (PTP1B) has been proposed to be an ideal target for treatment of type II diabetes and obesity. However, no druggable PTP1B inhibitor has been established and there is still an urgent demand for the development of structurally novel PTPIB inhibitor. Herein, we reported core-structurally novel PTP1B inhibitors with low micromole-ranged inhibitory activity by one-pot reaction from simple starting materials. Further studies demonstrated some of these active compounds had a specific selectivity over other PTPs. The structure and activity relationship was also described. The best active and selective compound 5e inhibited PTP1B activity with an IC50 of 4.53µM. Molecular docking analysis further demonstrated that compound 5e bound to the active pocket of PTP1B. The results might provide some insights for further development of new drugs for type II diabetes and obesity.

A Rh(ii)-catalyzed three-component reaction of 3-diazooxindoles with N,N-disubstituted anilines and glyoxylates for the synthesis of 3-aryl-3-substituted oxindoles.

A simple and effective method for the synthesis of 3-aryl-3-substituted oxindole derivatives via a [Rh]-catalyzed three-component reaction of 3-diazooxindoles with N,N-disubstituted anilines and glyoxylates is developed. This transformation is proposed to proceed through an intermolecular aldol-type trapping of zwitterionic intermediates.